Serotype-specific immunity and association with pneumococcal carriage following 3 1, 3 0 and 2 1 schedules of 10-valent pneumococcal conjugate vaccine.

Darren Suryawijaya Ong; Zheng Quan Toh; Beth Temple; Cattram Duong Nguyen; Thanh V Phan; Vo Thi Trang Dai; Anne Balloch; Rachel Ann Higgins; Belinda Daniela Ortika; Jemima Beissbarth; Kathryn Bright; Kien Vientrung; Leena Spry; Monica Larissa Nation; Nhung Vu Pham Hong; Nguyen Trong Toan; Pham Thi Hoan; Yin Bun Cheung; Heidi Smith-Vaughan; Catherine Satzke; Tran Ngoc Huu; Kim Mulholland; Paul V Licciardi

Journal article

Serotype-specific immunity and association with pneumococcal carriage following 3 1, 3 0 and 2 1 schedules of 10-valent pneumococcal conjugate vaccine.

Darren Suryawijaya Ong, Zheng Quan Toh, Beth Temple, Cattram Duong Nguyen, Thanh V Phan, Vo Thi Trang Dai, Anne Balloch, Rachel Ann Higgins, Belinda Daniela Ortika, Jemima Beissbarth, Kathryn Bright, Kien Vientrung, Leena Spry, Monica Larissa Nation, Nhung Vu Pham Hong, Nguyen Trong Toan, Pham Thi Hoan, Yin Bun Cheung, Heidi Smith-Vaughan, Catherine Satzke Show all

J Infect Dis | Published : 2026

DOI: 10.1093/infdis/jiag157

Abstract

BACKGROUND: Correlates of protection for pneumococcal carriage, a precursor for invasive pneumococcal disease, are not well defined. The relationship between memory B cells (Bmem) with carriage remains unclear. We assessed serotype-specific Bmem, IgG and opsonophagocytic (OPA) responses following different infant schedules of 10-valent pneumococcal conjugate vaccine (PCV10, Synflorix) and their association with pneumococcal carriage. METHODS: We analysed secondary outcome data from a phase II/III randomised controlled trial in Viet Nam (trial registration NCT01953510). Infants received PCV10 in a 3+1 (2-3-4-9 months), 3+0 (2-3-4 months) or 2+1 (2-4-9.5 months) schedule. Serotype-specific Bme..

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